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eSpira FM System肺功能檢測系統(tǒng)

eSpira™系統(tǒng)是用于檢測與肺功能相關(guān)的全部生理數(shù)據(jù)的大型系統(tǒng)，可對麻醉動物進(jìn)行一系列成組實(shí)驗(yàn)的數(shù)據(jù)自動分析檢測，包括用力肺活量相關(guān)數(shù)據(jù)的測試。廣泛應(yīng)用于COPD、肺間質(zhì)疾病、肺纖維化等疾病臨床前研究。

與人肺功能檢測相類似，eSpira™系統(tǒng)提供與人類肺功能指標(biāo)一致的各種生理指標(biāo)參數(shù)。該系統(tǒng)可用于小鼠、大鼠/豚鼠以及其他大型動物。系統(tǒng)高度自動化并提供豐富的圖標(biāo)供分析研究使用。

多參數(shù)肺功能檢測系統(tǒng)的主要檢測參數(shù)：

· 用力呼氣量Forced Expiratory Volume (FEV)

· 肺總量 Total Lung Capacity

· 用力肺活量Forced Vital Capacity

· * 大呼氣流量Peak Expiratory Flow

· * 大呼氣中段流量Maximum Mid Expiratory Flow

· 準(zhǔn)靜態(tài)壓力容積曲線Quasistatic Pressure Volume Curves

· 功能殘氣量FRC

· 阻力/順應(yīng)性Resistance/Compliance

· Explanations and more parameters

多參數(shù)肺功能檢測系統(tǒng)的產(chǎn)品主要特點(diǎn)：

· 適用于各種實(shí)驗(yàn)動物：小鼠、大鼠、豚鼠、犬、靈長類動物

· 經(jīng)典的肺量測定法（spirometry）檢測肺功能

· 綜合的肺功能分析

· COPD及肺間質(zhì)疾病研究的必備工具；

· 在數(shù)分鐘內(nèi)測定FEV(x)、FEF(x)、FVC、FRC、FEVpef、MMEF等參數(shù)；

· 氣道阻力和肺順應(yīng)性直接生理數(shù)據(jù)檢測；

· 軟件自動生成可直接打印的數(shù)據(jù)報(bào)告。

FM 動物肺功能檢測分析系統(tǒng) (Anesthetized) --大鼠肺功能測量，小鼠肺功能測量系統(tǒng)：

FM 動物肺功能檢測分析系統(tǒng)提供與人肺功能檢測相同的各種指標(biāo)參數(shù)，例如FEV(x)、FEF(x)、FVC、FRC、MMEF、TLC等用力呼吸相關(guān)的生理指標(biāo)；兼具彌散（DLCO）、Single Breath Nitrogen Washout等功能，廣泛應(yīng)用于COPD、肺間質(zhì)疾病、肺纖維化等疾病臨床前研究。

該系統(tǒng)同時(shí)也能夠檢測RC系統(tǒng)的阻力與動態(tài)肺順應(yīng)性等全部參數(shù)，并能檢測準(zhǔn)靜態(tài)肺順應(yīng)性（用于肺塌陷模型的研究）

eSpira FM System肺功能檢測系統(tǒng)/動物肺功能檢測分析系統(tǒng) (eSpira™ Forced Manoeuvers System)

eSpira FM System for Mouse

Spirometry is the most common method for assessing lung function within the clinical environment， with FEV1 (Forced Expiratory Volume in one second)， in particular， being the most characterised and utilised tests. Until recently， this method of assessing lung function was precluded within the laboratory， as it involved voluntary manoeuvres. However， the EMMS eSpira? system enables a researcher to perform classical spirometry lung function testing on anaesthetised animals.

Typically， animals are intubated or tracheostomised and cannulated. The animal’s lungs are inflated to a set tracheal pressure， and then exposed to a large negative pressure reservoir. This forces the subject to exhale as quickly as possible and enables the scientist to mimic classical clinical spirometry. Parameters calculated include Forced Expiratory Volume (FEVx)， where x is the time in milliseconds， Forced Vital Capacity and maximum mid expiratory flow， which gives an average flow over the middle part of the flow volume curve and is useful for determining mild to moderate airway obstruction.

The graph above illustrates data obtained using the eSpira system in a chronic murine model of asthma. Mice were sensitised with Ovalbumin and challenged on multiple occasions. Control animals were injected with alum only and were administered a saline aerosol. The lung function measurements were performed 24 hours after the last challenge. There was a 49% reduction in Forced Vital Capacity (FVC) and a 46% reduction in Forced Expiratory Volume in 50 milliseconds (FEV50). These data illustrate that the eSpira? system is capable of detecting lung function changes， in a murine asthma model， similar to those observed in the clinical environment.

Parameters Measured Include:

· Forced Expiratory Volume (FEV)

· Total Lung Capacity

· Forced Vital Capacity

· Peak Expiratory Flow

· Maximum Mid Expiratory Flow

· Quasistatic Pressure Volume Curves

· FRC

· Resistance/Compliance

· Explanations and more parameters

Features

· Available for all common species from mouse to primate

· Replicates classical spirometry lung function testing

· Comprehensive lung function analysis

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Uses

· Acute and Chronic models

· Recovery anaesthesia protocols

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